Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-09-17
1987-10-06
Warren, Robert J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546156, A61K 3147, C07D21518
Patent
active
046983503
ABSTRACT:
1-Ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinoline carboxylic acid (Win 52,522) or salt thereof, a highly potent antibacterial agent, is prepared by nitrating the corresponding 6-desfluoro compound (Win 35,439) to produce the corresponding 6-nitro compound, reducing the latter compound to produce the corresponding 6-amino compound and converting the 6-amino via its diazonium salt to said 6-fluoro compound (Win 52,522). Comparative in vitro and in vivo antibacterial test data are provided to demonstrate the uniqueness of Win 52,522 as a highly potent antibacterial agent having a broad spectrum of antimicrobial activity.
REFERENCES:
patent: 3753993 (1973-08-01), Lesher et al.
patent: 3907808 (1975-09-01), Lesher
patent: 4146719 (1979-03-01), Irikura
patent: 4292317 (1981-09-01), Pesson
patent: 4533735 (1985-08-01), Walter
patent: 4554352 (1985-11-01), Ranken
Albrecht-Progress in Drug Research 21, pp. 35-45, 1977.
Morrison, Organic Chemistry, 2nd Edition, pp. 824 and 825, (1970) Allyn and Bacon.
Daum Sol J.
Lesher George Y.
Bair Robert K.
Benson Robert
DuPont Paul E.
Johnson Thomas L.
Sterling Drug Inc.
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