1,5-benzothiazepine derivatives, their preparation and their use

Details 1,5-benzothiazepine derivatives, their preparation and their use 1,5-benzothiazepine derivatives, their preparation and their use

1989-07-21

1991-03-26

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540491, A61K 3155, C07D41712

Patent

active

050029428

ABSTRACT:
Compounds of formula (I): ##STR1## in which: R.sup.1 is aryl or aromatic heterocyclic; R.sup.2 and R.sup.3 are hydrogen, alkyl, alkoxy, halogen, phenyl, phenoxy, C.sub.1 -C.sub.6 alkylthio, phenylthio, C.sub.1 -C.sub.6 haloalkyl, cyano or nitro, or together are alkylene optionally containing oxygen; R.sup.4 is hydrogen, aliphatic acyl, cycloalkylcarbonyl, cycloalkoxycarbonyl, aromatic acyl, alkoxycarbonyl or benzyloxycarbonyl; R.sup.5 and R.sup.6 are alkyl; and X is oxygen, sulfur or methylene, have calcium channel blocking activity and can serve for the treatment or prophylaxis of cardiovascular diseases and disorders. They may be prepared by reacting a corresponding compound where R.sup.4 is hydrogen and the aminoethyl group is replaced by hydrogen with a compound providing the aminoethyl group and the, if required, acylating the product.

REFERENCES:
patent: 4370340 (1983-01-01), Ueda et al.
patent: 4438126 (1984-03-01), Ueda et al.
patent: 4567175 (1986-01-01), Takeda et al.
patent: 4590188 (1986-05-01), Takeda et al.
patent: 4594342 (1986-06-01), Takeda et al.

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