1,4-disubstituted piperazines

Details 1,4-disubstituted piperazines 1,4-disubstituted piperazines

1999-03-18

2000-10-17

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

51425301, 51425312, 51425313, 51425401, 51425503, 544295, 544360, 544372, 544380, A61K 31496, C07D40104, C07D295073, C07D295155

Patent

active

061332682

ABSTRACT:
The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.

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Plilai et al, Indian J. Chem., vol. 14B, p. 714-716 (1976).
Sindelar et al., Collection Czech. Chem. Commun., vol. 59, pp. 667-674 (1994).

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