1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates usefu

Details 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates usefu 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates usefu

1991-01-28

1993-06-01

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546286, C07D21355, C07D21357, A61K 3144

Patent

active

052161722

ABSTRACT:
Agents against drug-resistant tumor cells comprising a 1,4-dihydropyridine derivative represented by the following formula (I): ##STR1## wherein R.sup.1 is an aryl group which may be substituted;

REFERENCES:
patent: 3511847 (1970-05-01), Loev et al.
patent: 4284634 (1981-08-01), Satu
patent: 4520131 (1985-05-01), Loev et al.
Chemical & Pharmaceutical Bulletin, vol. 27, No. 6, Jun. 1979, pp. 1426-1440; M. Iwanami et al., "Synthesis of new water-soluble dihydropyridine vasodilators".
Chemical Abstracts, vol. 90, No. 15, Apr. 9, 1979, p. 623, left-hand column, Abstract No. 121362m, Columbus, Ohio, US; A. Sausins et al., "N-Alkylation of 1,4-dihydropyridine-3,5-dicarboxylic acid esters", Khim., Geterotsikl. Soedin. 1978, No. 11, pp. 1508-1513.
Patent Abstracts of Japan, vol. 7, No., 273 (C-198)(1418), Dec. 6, 1983.
Patent Abstracts of Japan, vol. 9, No. 188 (C-295)(1911), Aug. 3, 1985.

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