1,4-benzothiazine-2-acetic acid derivatives

Details 1,4-benzothiazine-2-acetic acid derivatives 1,4-benzothiazine-2-acetic acid derivatives

1991-12-24

1993-10-12

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 52, A61K 3154, C07D27916

Patent

active

052525716

ABSTRACT:
1,4-Benzothiazine-2-acetic acid derivatives having an excellent aldose reductase inhibitory activity which are useful for the prevention and treatment of diabetic complications, such as diabetic cataract, retinopathy, nephropathy and neuropathy.

REFERENCES:
patent: 3503965 (1990-03-01), Langis
patent: 3910904 (1975-10-01), Worley
Chemical And Pharmaceutical Bulletin, vol. 20, No. 4, Apr., 1972, pp. 832-834, Y. Maki,et al., "Further Studies on the Reaction of 2-Aminothiophenol with Dimethyl Acetylenedicarboxylate".
Chemical And Pharmaceutical Bulletin, vol. 24, No. 9, pp. 2250-2253, 1976, Y. Maki, et al., "Facile Thermal Dimerization of a Photochemically Isomerized Olefin".

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