1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives, acid addition

Details 1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives, acid addition 1-(4-Aminobenzyl)-2,3-dioxopiperazine derivatives, acid addition

1982-02-12

1984-07-17

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544367, 544369, 544370, 544372, 544373, 544374, 424250, C07D40310, C07D40312, A61K 31495

Patent

active

044607741

ABSTRACT:
A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: ##STR1## and an acid addition salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.

REFERENCES:
patent: 4110327 (1978-08-01), Saikawa et al.
Hori et al., Chem. and Pharm. Bulletin, 29, (3), pp. 684-698, (1980), 29, (6), pp. 1594-1605, (1981).

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