1,4,5,6-Tetrahydropyrimidine derivatives

Details 1,4,5,6-Tetrahydropyrimidine derivatives 1,4,5,6-Tetrahydropyrimidine derivatives

1978-05-08

1983-04-12

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

424251, 4242484, 542458, 544242, 544330, 544332, 544333, 544335, C07D41306, C07D23906, A61K 31505, A61K 31535

Patent

active

043799264

ABSTRACT:
1,4,5,6-Tetrahydropyrimidine derivatives characterized by having a phenyl or substituted phenyl at positions 1 and 6 in addition being further substituted at position 2. The foregoing compounds are useful as diuretic agents in a mammal. Methods for the preparation and use of the compounds are disclosed.

REFERENCES:
patent: 2658895 (1953-11-01), Ballard et al.
patent: 3126381 (1964-03-01), Langis et al.
patent: 3332948 (1967-07-01), Blatter
patent: 3814758 (1974-06-01), Kessler et al.
patent: 3926994 (1975-12-01), White et al.
patent: 4003718 (1977-01-01), Gattuso et al.
patent: 4007200 (1977-02-01), Panzer et al.
Skinner et al., "J. Amer. Chem. Soc.", vol. 73, 1951, pp. 3814.
Faust et al., "J. Org. Chem.", vol. 26, 1961, pp. 4044.

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