1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates

Details 1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates 1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates

1991-07-26

1993-01-12

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514278, 514339, 514333, 514414, 514418, 548411, 548468, 548410, 548483, 546256, 546273, 546 17, A61K 31405, C07D20934

Patent

active

051791196

ABSTRACT:
This invention relates to 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones of the formula ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are independently hydrogen, loweralkyl, aryl, arylloweralkyl or heteroarylloweralkyl selected from the group consisting of pyridinylmethyl, pyridinylethyl, thienylmethyl, thienylethyl; or R.sub.2 and R.sub.3 together form a cycloalkane ring of 4 to 6 carbons or a spiro-fused aryl cycloalkane or heterocycloalkyl selected from the group consisting of piperidine and tetrahydropyran; X and Y are independently hydrogen, halogen, hydroxy, loweralkyl, loweralkoxy, nitro, amino or trifluoromethyl; m and n are independently integers of 1 to 3, the pharmaceutically acceptable acid addition salts thereof and, where applicable the optical, geometrical and stereoisomers and racemic mixtures thereof. The compounds of this invention display utility as analgesics, anticonvulsants, for enhancing memory and for the treatment of Alzheimer's disease.

REFERENCES:
patent: 3975531 (1976-08-01), Welstead, Jr. et al.
patent: 5064852 (1991-11-01), Howard, Jr. et al.

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