Process for preparing daunorubicin and doxorubicin

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

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43525235, 536 231, C12P 1956, C12N 120, C07H 2102

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active

059898690

ABSTRACT:
The present invention is directed to a process for improving daunorubicin and doxorubicin production by means of a recombinant microorganism in which a gene of daunorubicin metabolism involved in the glycosylation of daunorubicin to acid-sensitive, baumycin-like compounds is inactivated.

REFERENCES:
Hutchinson, C. et al., Antonie van Leeuwenhoek, vol. 64, pp. 165-176, 1993.
Scotti, C. et al., J. Bacter., vol. 178, pp. 7316-7321, Dec. 1996.

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