Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-07-18
1980-01-22
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2603974, 26039747, 26039745, 26023955D, A61K 3156, C07J 500
Patent
active
041851013
ABSTRACT:
1,3,5(10),6,8-19-Nor-pregnapentaene-20-ones exhibit anti-mitotic activity with minimal or no hormonal activity. They are particularly useful in the treatment and control of psoriasis when applied topically, preferred anti-psoriatic compounds being 1,3,5(10),6,8-19-nor-pregnapentaene-3,17.alpha.,21-triol-20-one 21-acetate and the 16.alpha.-methyl and 16.beta.-methyl analogs thereof.
The 1,3,5(10),6,8-19-nor-pregnapentaene-20-ones are also useful as intermediates in the preparation of the corresponding 14-dehydro compounds which also exhibit anti-mitotic activity as described and claimed in copending application Ser. No. 819,182 filed July 26, 1977 of Richard W. Draper and Charles J. Casmer of common assignee as this application, and now abandoned.
REFERENCES:
patent: 3116289 (1963-12-01), Tanabe
patent: 3182057 (1965-05-01), Heller et al.
patent: 3182075 (1965-05-01), Heller et al.
patent: 3282929 (1966-11-01), Heller et al.
Heller et al., J.A.C.S. (1967) vol. 89, pp. 1911-1925.
Casmer Charles J.
Draper Richard W.
Green Michael J.
King Mary S.
Roberts Elbert L.
Schering Corporation
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