1,3,4-thiadiazoles and 1,3,4-Oxadiazoles as .alpha..sub.v .beta.

Details 1,3,4-thiadiazoles and 1,3,4-Oxadiazoles as .alpha..sub.v .beta. 1,3,4-thiadiazoles and 1,3,4-Oxadiazoles as .alpha..sub.v .beta.

1998-11-25

2000-11-28

Davis, Zinna Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5462687, 5462691, 514342, C07D41700

Patent

active

061536288

ABSTRACT:
This invention relates to 1,3,4-thiadiazoles and 1,3,4-Oxadiazoles of Formula (I) which are useful as antagonists of .alpha..sub.v .beta..sub.3 and related integrin receptors, to pharmaceutical compositions containing such compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion and the tretment of angioginic disorders, inflammation, bone degradation, tumors, metastases, thrombosis, and other cell aggregation-related conditions.

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