Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-08-22
1998-06-16
Peselev, Elli
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 2, 514 8, 514802, 514822, 530393, 530395, 536 21, A61K 3170
Patent
active
057671087
ABSTRACT:
A method of treating a patient with a medical device having immobilized heparin on a blood-contacting surface in which the covalently attached heparinized surface is provided with an adsorbed protein which may be activated by the immobilized heparin to block the coagulation of fibrinogen. Antithrombin III is the preferred adsorbed protein. The adsorbed protein is maintained on the immobilized heparin surface until the medical device is placed into contact with the patient's blood. When in contact with the patient's blood, the adsorbed protein will prevent initial thrombin formation at the biomaterial-blood interface. The preadsorption of ATIII is accomplished under conditions advantageous to maximum heparin/ATIII binding. When the preadsorbed surface comes in contact with whole blood, the maximum advantage of prophlactic properties of ATIII/heparin are obtained.
REFERENCES:
patent: 3639141 (1972-02-01), Dyck
patent: 3826678 (1974-07-01), Hoffman et al.
patent: 4118485 (1978-10-01), Eriksson et al.
patent: 4521564 (1985-06-01), Solomon et al.
patent: 4526714 (1985-07-01), Feijen et al.
patent: 4565740 (1986-01-01), Golander et al.
patent: 4600652 (1986-07-01), Solomon et al.
patent: 4613665 (1986-09-01), Larm
patent: 4634762 (1987-01-01), Feijen et al.
patent: 4642242 (1987-02-01), Solomon et al.
patent: 4673584 (1987-06-01), Nygren et al.
patent: 4720512 (1988-01-01), Hu et al.
patent: 4786556 (1988-11-01), Hu et al.
patent: 5032666 (1991-07-01), Hu et al.
patent: 5049403 (1991-09-01), Larm et al.
patent: 5053048 (1991-10-01), Pinchuk
patent: 5055316 (1991-10-01), Hoffman et al.
patent: 5077372 (1991-12-01), Hu et al.
patent: 5132108 (1992-07-01), Narayanan et al.
patent: 5229172 (1993-07-01), Cahalan et al.
patent: 5292724 (1994-03-01), Kita
patent: 5308641 (1994-05-01), Cahalan et al.
patent: 5319072 (1994-06-01), Uemura et al.
patent: 5350800 (1994-09-01), Verhoeven et al.
patent: 5356433 (1994-10-01), Rowland et al.
patent: 5415938 (1995-05-01), Cahalan et al.
Blezer Ron
Cahalan Linda
Cahalan Patrick
Fouache Benedict
Hendriks Marc
Latham Daniel W.
Medtronic Inc.
Patton Harold R.
Peselev Elli
LandOfFree
Method for making improved heparinized biomaterials does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for making improved heparinized biomaterials, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for making improved heparinized biomaterials will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1726208