1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils

Details 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils

1987-05-11

1989-09-05

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544309, 544313, 544314, A61K 31505, C07D23954, C07D23955

Patent

active

048639273

ABSTRACT:
1-[2-(Hydroxymethyl)cycloalkylmethyl]-5-substituted uracils which are herpes simplex viral thymidine kinase inhibitors, their acyl derivatives, and their pharmaceutically-acceptable salts; pharmaceutical formulations containing these compounds; the treatment of DNA viral, particularly herpes viral, infections with these compounds; methods of preparing these compounds; and novel intermediates useful in their preparation.

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patent: 4617304 (1986-10-01), Ashton et al.
Colla et al, J. Med. Chem. 1983, 26, 602-604, "Synthesis and Antiviral Activity of Water-Soluble Esters of Acyclovir".
Baerwolff et al, CA 100-156945f (1984) "5-(2,2-Disubstituted) Uracil Derivatives".
Cooper, CA 100-91365v "Penetrating Topical Pharmaceutical Compositions Containing 9-(2-Hydroxyethoxymethyl)Guanine".
Verheyden et al, CA 100-7067u "Substituted 9-(1 or 3-Monoacyloxy or 1,3-Diacyloxy-2-Propoxymethyl) Purines as Antiviral Agents".
Griengl et al, CA 100-210358g "Deoxyuridine Derivatives and Their Use as Pharmaceuticals".
Johansson et al, CA 104-50735e "Guanine Derivatives, Their Pharmaceutical Composition and Selectivity Combatting Viruses".
R. J. Klein, Antiviral Res., Suppl. 1, pp. 111-120, (1985).

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