[1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrate

Details [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrate [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrate

1983-04-29

1985-07-02

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546278, 548318, C07D23364

Patent

active

045269815

ABSTRACT:
1,3-Dihydro-2H-imidazol-2-ones having 5-acyl and 4-oxymethyl substituents, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate alcohol or a silver salt with a substituted 4-bromomethyl-1,3-dihydro-2H-imidazol-2-one.

REFERENCES:
patent: 2397250 (1946-03-01), Duschinsky
patent: 2441933 (1948-05-01), Duschinsky
patent: 2514380 (1950-07-01), Duschinsky
patent: 3303199 (1967-02-01), Doebel et al.
Dage, R., et al., Fed. Proc. 39:1105 (1980)-abstract only.
Duschinsky, R., et al., J. Am. Chem. Soc., 68, 2350 (1946).
Chemical Abstracts, 90:137,731s (1979), [Zav'yalov, S., et al., Izv. Akad. Nauk. SSSR, Ser. Khim. 1979, (1), 225-226].
Duschinsky, R., et al., J. Am. Chem. Soc., 70, 657 (1948).

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