Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-01-26
1997-04-29
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142318, 5142322, 5142342, A61K 3153, A61K 31535
Patent
active
056249250
ABSTRACT:
A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosentitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4- benzotriazine oxides is also disclosed.
REFERENCES:
Zemah et al, I.J. Radiation Oncology Biol. Phys, vol. 12, No. 7, pp. 1239-1242 (Jul. 1986).
Brown J. Martin
Grange Edward W.
Lee William W.
Martinez Abelardo P.
Pollart Daniel J.
Balogh Imre
Davis William J.
DuPont Paul E.
Goldberg Jerome D.
SRI - International
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