1,2,3,4-tetrahydro-6-substituted-4-aryl-3-substituted-2-thioxo(o

Details 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-substituted-2-thioxo(o 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-substituted-2-thioxo(o

1986-03-14

1987-08-04

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544316, 544318, A61K 31505, C07D23922

Patent

active

046846557

ABSTRACT:
Cardiovascular activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur;

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George et al., Synthesis (1975) pp. 405-407, "Condensed Heterocycles from 5-Ethoxycarbonyl-6-Methyltetrahydropyrimidin-2-Ones".
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J. Org. Chem., vol. 50, pp. 4227-4230, "Synthesis of Novel Dihydropyrimidines and Tetrahydropyrimidines", Cho et al.(1985).
Chemical Abstracts, 1955:14769I, "Synthesis of Some 2-Oxo-4-Aryl-5-Carbethoxy-6-Trifluoromethyl-1,2,3,4-Tetrahydropyrimidines" , Rutter et al.
Chemical Abstracts 1944:2653(4), "Synthesis of the Ethyl Esters of Some 2-Oxo-2-Thio-1,2,3,4-Tetrahydro-5-Pyrimidinecarboxylic Acids", McKinstry.
Chemical Abstracts 1944:4318(4), "The Chemotherapy of Experimental Virus Infections", McKinstry et al.

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