Piperazinyl pyrimidine dione compounds selective for adrenocepto

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514243, 514245, 514246, 514248, 514249, 51425202, 51425211, 51425217, 544184, 544194, 544212, 544236, 544257, 544258, 544262, 544266, 544267, 544268, 544278, 544279, 544280, A61K 31496, A61K 314353, C07D48706, C07D47500, C07D48700

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active

061660191

ABSTRACT:
Compounds of Formula I and II and their pharmaceutically acceptable, salts, esters and prodrugs thereof are selective alpha-1D adrenoceptor anatagonists and may be useful for treating disease states.

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patent: 5521181 (1996-05-01), Meyer et al.
Romeo, G., et al., "Heterocyclic Systems Containing the Pyrimido-2,4-Dione Ring as Selective Ligands for the .alpha..sub.1 -Adrenoceptors", IL Farmaco, 50(6):471-477 (1995).
Russell, R. K., et al., "Thiophene Systems. 9. Thienopyrimidinedione Derivatives as Potential Antihypertensive Agents", J. Med. Chem., 31:1786-1793 (1988.

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