Process for preparing 2-chloro-benzimidazole derivatives

Details Process for preparing 2-chloro-benzimidazole derivatives Process for preparing 2-chloro-benzimidazole derivatives

1998-07-17

2000-04-25

Stockton, Laura L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23502, C07D491056

Patent

active

060545895

ABSTRACT:
A novel process for the preparation of 2-chloro-benzimidazole derivatives of the formula ##STR1## in which A represents optionally halogenated alkylene having 1 or 2 carbon atoms,
which process comprises reaction 1,3-dihydro-benzimidazol(ethi)ones of the formula ##STR2## in which X represents oxygen or sulphur,
with phosphorus oxychloride.
Novel 1,3-dihydro-benzimidazol(ethi)ones of the formula(II) and process for their preparation.

REFERENCES:
patent: 4686230 (1987-08-01), Rainer et al.
patent: 4758579 (1988-07-01), Kohl et al.
patent: 4766133 (1988-08-01), Fischli et al.
patent: 5587389 (1996-12-01), Kohl et al.
Patent Abstract of Japan, vol. 12, No. 433 (C-543), Nov. 1998 & JP 63 159383 A (Taisho Pharmaceut Co LTD) Jul. 2, 1998.
J. Chem. Soc. (month unavailable) 1963, p. 2930.

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