Phosphonic acid derivatives

Details Phosphonic acid derivatives Phosphonic acid derivatives

1997-04-24

2000-04-25

Ambrose, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 80, 514 95, 514 99, 514120, 514114, 546 22, 546 25, 548414, 549 6, 549218, 549222, 558179, 562 24, A61K 31675, A61K 3167, A61K 31665, A61K 3166, C07F 96553, C07F 9655, C07F 958, C07F 9572, C07F 940

Patent

active

060544449

ABSTRACT:
The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.

REFERENCES:
patent: H1312 (1994-05-01), Coughlin et al.
patent: 4052160 (1977-10-01), Cook et al.
patent: 4151172 (1979-04-01), Ondetti et al.
patent: 4168267 (1979-09-01), Petrillo, Jr.
patent: 4316896 (1982-02-01), Thorsett et al.
patent: 4337201 (1982-06-01), Petrillo, Jr.
patent: 4374131 (1983-02-01), Petrillo, Jr.
patent: 4444765 (1984-04-01), Karanewsky et al.
patent: 4448772 (1984-05-01), Karanewsky
patent: 4452790 (1984-06-01), Karanewsky et al.
patent: 4452791 (1984-06-01), Ryono et al.
patent: 4468519 (1984-08-01), Krapcho
patent: 4547324 (1985-10-01), Wong et al.
patent: 4555506 (1985-11-01), Karanewsky et al.
patent: 4560680 (1985-12-01), Ryono et al.
patent: 4560681 (1985-12-01), Karanewsky
patent: 4567166 (1986-01-01), Karanewsky et al.
patent: 4616005 (1986-10-01), Karanewsky et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4703043 (1987-10-01), Karanewsky et al.
patent: 4715994 (1987-12-01), Parsons et al.
patent: 4716155 (1987-12-01), Karanewsky et al.
patent: 4741900 (1988-05-01), Alvarez et al.
patent: 4849525 (1989-07-01), Weller, III et al.
patent: 4853326 (1989-08-01), Quash et al.
patent: 4867973 (1989-09-01), Goers et al.
patent: 4885283 (1989-12-01), Broadhurst et al.
patent: 4906779 (1990-03-01), Weber et al.
patent: 4918064 (1990-04-01), Cordi et al.
patent: 4937183 (1990-06-01), Ultee et al.
patent: 4950738 (1990-08-01), King et al.
patent: 4959493 (1990-09-01), Ohfume et al.
patent: 4962097 (1990-10-01), Parsons et al.
patent: 4988681 (1991-01-01), Ishikawa et al.
patent: 4994446 (1991-02-01), Sokolovsky et al.
patent: 5030732 (1991-07-01), Morita et al.
patent: 5041644 (1991-08-01), Morita et al.
patent: 5047227 (1991-09-01), Rodwell et al.
patent: 5061806 (1991-10-01), Morita et al.
patent: 5093525 (1992-03-01), Weber et al.
patent: 5099063 (1992-03-01), Parsons et al.
patent: 5136080 (1992-08-01), Miller et al.
patent: 5140104 (1992-08-01), Coughlin et al.
patent: 5143908 (1992-09-01), Parsons et al.
patent: 5145990 (1992-09-01), Parsons et al.
patent: 5147867 (1992-09-01), Parsons et al.
patent: 5156840 (1992-10-01), Goers et al.
patent: 5162504 (1992-11-01), Horoszewicz
patent: 5162512 (1992-11-01), King et al.
patent: 5190976 (1993-03-01), Weber et al.
patent: 5196510 (1993-03-01), Rodwell et al.
patent: 5242915 (1993-09-01), Ueda et al.
patent: 5262568 (1993-11-01), Weber et al.
patent: 5326856 (1994-07-01), Coughlin et al.
patent: 5336689 (1994-08-01), Weber et al.
patent: 5449761 (1995-09-01), Belinka, Jr. et al.
patent: 5474547 (1995-12-01), Aebischer et al.
patent: 5489525 (1996-02-01), Pastan
patent: 5495042 (1996-02-01), Belinka, Jr. et al.
patent: 5500420 (1996-03-01), Maiese
patent: 5508273 (1996-04-01), Beers et al.
patent: 5527885 (1996-06-01), Coughlin et al.
patent: 5538866 (1996-07-01), Israeli et al.
patent: 5538957 (1996-07-01), Tsaklakidis et al.
patent: 5594007 (1997-01-01), Chenard
Vornov, James J., "Toxic NMDA-Receptor Activation Occurs During Recovery in a Tissue Culture Model of Ischemia," J. of Neurochemistry, (1995) 65:4, 1681-1691.
Slusher, Barbara S. et al., "Rat Brain N-Acetylated .alpha.-Linked Acidic Dipeptidase Activity," J. of Biological Chemistry, (1990) 265:34, 21297-21301.
Slusher, Barbara S. et al., "Immunocytochemical Localization of the N-Acetyl-Aspartyl-Glutamide (NAAG) Hydrolyzing Enzyme N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase)," J. of Comparative Neurology, (1992) 315, 217-229.
Slusher, Barbara S., "NAALADase: A Potential Regulator of Synaptic Glutamate," Biotech Update DuPont NEN, (1994) 9:2, 37-39.
Jackson, Paul F. et al., "Design, Synthesis, and Biological Activity of a Potent Inhibitor of the Neuropeptidase N-Acetylated .alpha.-Linked Acidic Dipeptidase," J. of Medicinal Chemistry, (1995) 39:2, 619-622.
Carter, Ruth E. et al., "Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase," Proc. Natl. Acad. Sci. USA, (1996) 93, 749-753.
Heston, W.D.W., "Potential Uses of Prostate Specific Membrane Antigen (PMSA) : a Neurocarboxypeptidase and Membrane Folate Hydrolase," Urologe [A], v. 35, pp. 400-407 (1996).
Hurn, P., "Gender-Linked Injury After Focal Cerebral Ischemia," Society for Neuroscience 1996 Abstract Form, (1996).
Bhardwaj, A., "Striatal Nitric Oxide (NO) Production is Enhanced In Focal Cerebral Ischemia: An In Vivo Microdialysis Study," Society for Neuroscience 1996 Abstract Form, (1996).
Stauch, Barbara L. et al., "The effects of N-acetylated alpha-linked acidic dipeptidase (NAALADase) inhibitors on [.sup.3 H]NAAG catabolism in vivo," Neuroscience Letters, (1989) 100, 295-300.
Meyerhoff, James L. et al., "Activity of a NAAG-hydrolizing enzyme in brain may affect seizure susceptibility in genetically epilepsy-prone rats," Molecular Neurobiology of Epilepsy, (1992) Chap. 16, 163-172.
Subasinghe, N. et al., "Synthesis of acylic and dehydroaspartic acid analogues of Ac-Asp-Glu-OH and their inhibition of rat brain N-acetylated .alpha.-linked acidic dipeptidase (NAALA dipeptidase)," J. Med. Chem, (1990) 33, 2734-2744.
Coyle, J. et al., "N-acetyl-aspartyl glutamate," Excitatory Amino Acids, (1991) 69-77.
Tsai, G. et al., "Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis," Brain Research, (1991) 556, 151-156.
Tsai, G. et al., "Changes of excitatory neurotransmitter metabolism in schizophrenic brains," Salmon Lecturer of the New York Academy of Medicine (Dec. 2-3, 1993).
Rothstein, J. et al., "Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis," Anals of Neurology, (1990) 28:1, 18-25.
Tsai, G. et al., "Immunocytochemical distribution of N-acetylaspartylglutamate in the rat forebrain and glutamatergic pathways," J. of Chem. Neuroanatomy, (1993) 6, 277-292.
Koenig, M. et al., "N-acetyl-aspartyl-glutamate (NNAG) elicits rapid increase in intraneuronal Ca.sup.2+ in vitro," NeuroReports, (1994) 5, 1063-1068.
Woods, D. et al., "Gender-linked injury after focal ischemia," Soc. for Neuroscience 1996 Abstract Form, (1996).
Myerhoff, J. et al., "Genetically epilepsy-prone rats have increased brain regional activity of an enzyme which liberates glutamate from N-acetyl-aspartyl-glutamate," Brain Research, (1992) 593, 140-143.
Anderson, Vernon E. and W.W. Cleland. 1990. Biochemistry. 29: 10498-10503.
Blackburn, G. Michael and Abdul Rashid. 1988. J. Chem. Soc. Chem. Commun. (4): 317-319.
McFadden, Helen G. et al. 1987. Aust. J. Chem. 40:1619-1629.
Grobelny, Damian et al. 1985. Biochem. J. 232: 15-19.
Pfeiffer, Francis R. et al. 1974. J. Med. Chem. 17(1): 112-115.
Grobelny, Damian et al. Database CAPLUS on STN.RTM. International. 1990. Accession No. 1990:94404. [Biochemistry. 28(12): 4948-4951 (1990)].

Affiliated with

Also associated with

Rating

Phosphonic acid derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phosphonic acid derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phosphonic acid derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-993482