Food or edible material: processes – compositions – and products – Products per se – or processes of preparing or treating... – Basic ingredient lacteal derived other than butter...
Patent
1995-06-05
1998-05-12
Crouch, Deborah
Food or edible material: processes, compositions, and products
Products per se, or processes of preparing or treating...
Basic ingredient lacteal derived other than butter...
435 691, 435 694, 435 6951, 435 6952, 435 696, 435183, 435215, 800 2, 800DIG1, C12P 2106, C12P 2102, C12P 2104
Patent
active
057501726
ABSTRACT:
This invention relates to the production of recombinant proteins, such as coagulation factors VIII and IX, tissue plasminogen activator (TPA), urokinase, growth hormone, insulin, interferons, interleukins, peptide hormones and immunoglobulins, in mammals' milk. Particularly, this invention relates to an expression system which when transgenically incorporated into a mammal permits the female species of that mammal to produce the desired recombinant protein in or along with its milk. This invention also relates to the transgenic mammal that produces the desired recombinant product in its milk.
REFERENCES:
patent: 5304489 (1994-04-01), Rosen
patent: 5322775 (1994-06-01), Clark et al.
patent: 5565362 (1996-10-01), Rosen
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Clark et al., "Pharmaceuticals from Transgenic Livestock", Trends in Biotechnology, vol. 5, pp. 20-24, Jan. 1987.
Hanahan, "Heritable Formation of Pancreatic beta-Cell Tumours in Transgenic Mice Expressing Recombinant Insulin/Simian Virus 40 Oncogenes", Nature, vol. 315, pp. 115-122, May 9, 1985.
Overbeek et al., "Lens-specific Expression and Developmental Regulation of the Bacterial Chloramphenicol Acetyltransferase Gene Driven by the Murine alphaA-Crystallin Promoter in Transgenic Mice", Proceedings of the National Academy of Sciences USA, Volum, Dec. 1985.
Yu-Lee et al., "Evolution of the Casein Multigene Family: Conserved Sequences in the 5' Flanking and Exon Regions", Nucleic Acids Research, vol. 14, No. 4, pp. 1883-1902, 1986.
Campbell et al., "Comparison of the Whey Acidic Protein Genes of the Rat and Mouse", Nucleic Acids Research, vol. 12, Nov. 22, pp. 8685-8697, 1984.
Lonberg Nils
Meade Harry
Crouch Deborah
Pharming B.V.
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