Method of treating pruritus with nalmefene and clonidine

Details Method of treating pruritus with nalmefene and clonidine Method of treating pruritus with nalmefene and clonidine

1989-02-21

1990-08-07

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A31K 31485

Patent

active

049468480

ABSTRACT:
A method of treating a mammal suffering from pruritus, whether antigen-induced or disease-induced, comprising orally administering to the subject from about 1 to about 25 mg of the narcotic antagonist nalmefene for an initial period of 1 to 7 days, and gradually increasing the dosage level of nalmefene by increments of 1 to 25 mg per day during successive periods of 1 to 7 days to a maximum of 150 mg per day. Clonidine or clonidine hydrochloride may be administered concomitantly with the nalmefene to alleviate opioid withdrawal symptoms.

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