Antihypertensive 1,2-benzisothiazole piperidines

Details Antihypertensive 1,2-benzisothiazole piperidines Antihypertensive 1,2-benzisothiazole piperidines

1984-04-23

1985-07-09

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546198, C07D41704, A61K 31425

Patent

active

045282927

ABSTRACT:
There are described novel antihypertensive 1,2-benzisothiazole piperidines of the formula ##STR1## where X is hydrogen, halogen, loweralkoxy, loweralkyl, nitro, amino or trifluoromethyl; and R is ##STR2## R.sub.1 being loweralkyl, aryl, aralkyl, cycloalkylloweralkyl or a loweralkyl substituted with an amino, loweralkylamino or diloweralkylamino, and R.sub.2 being hydrogen, loweralkyl or aryl; antihypertensive compositions comprising said compounds or pharmaceutically acceptable acid addition salts thereof; and methods for synthesizing the same.

REFERENCES:
patent: 4355037 (1982-10-01), Strupczewski et al.
Winthrop et al., "J. Org. Chem.", vol. 24, pp. 1936-1939, (1956).
Steindorff, "Chem. Ber.", vol. 37, pp. 963-966, (1904).
March, "Advanced Organic Chemistry: Reactions, Mechanisms and Structure", (McGraw-Hill) (1968), p. 664.

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