Use of, and method of treatment using, hydroxycarbazole compound

Details Use of, and method of treatment using, hydroxycarbazole compound Use of, and method of treatment using, hydroxycarbazole compound

1993-11-24

1995-02-28

Killos, Paul J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514411, A61K 3140

Patent

active

053937724

ABSTRACT:
The present invention provides a new medical use of the hydroxycarbazole compounds of Formula (I), preferably the hydroxylated metabolites of 1-(carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol)(carve dilol), for inhibiting the migration and proliferation of smooth muscle cells. In particular, the present invention provides a new use for the hydroxycarbazole compounds of Formula (I) for prevention of restenosis following percutaneous transluminal coronary angioplasty (PTCA), suppression of the progression of vascular hypertrophy associated with hypertension, and prevention of development of atherosclerosis. ##STR1## wherein: R.sub.1 -R.sub.9 are independently --H or --OH, with the proviso that a at least one of R.sub.1 -R.sub.9 is OH.

REFERENCES:
patent: 5308862 (1994-04-01), Ohlstein
Albrightson, C et al Pharmacol. Commun. (1992) 1(4) 267-272.
Ohlstein, E et al Proc. Natl. Acad. Sci U.S.A. 1993 90(13) 6189-93.
Sung, C et al, J. Cardiovasc. Pharmacology (1993) 21(2), 221-7.

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