Preparation of acylated glycerophosphocholines and glycerophosph

Details Preparation of acylated glycerophosphocholines and glycerophosph Preparation of acylated glycerophosphocholines and glycerophosph

1986-07-29

1988-01-05

Hollrah, Glennon H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26050112, 558169, C07F 910, A61K 31685

Patent

active

047175125

ABSTRACT:
Preparation of chemically defined pure enantiomeric 1,2-diacyl-sn-glycero-3-phosphocholines and 1,2-diacyl-sn-glycero-3-phosphoethanolamines which are substituted in positions 1 and 2 of the glycerol, by acylation of triphenylmethyl derivatives of sn-glycero-3-phosphocholine and sn-glycero-3-phosphoethanolamine.

REFERENCES:
patent: 4622180 (1986-11-01), Paltauf et al.
H. Eibl, Synthesis of Glycerophospholipids, Chemistry and Physics of Lipids (1980), pp. 405-429.
H. Eibl, Phospholipids, Angewandete Chemie (1984), pp. 247-262.
The Nomenclature of Lipids, Biochem J. (1978), pp. 21-35.
McOmie, Protective Groups in Organic Chemistry, 1973, pp. 100-103.
Daubert, Jor. of Amer. Chem. Soc., vol. 62, 1940, pp. 1713-1716.

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