Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-08-26
1998-11-03
O'Sullivan, Peter
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514357, 514396, 514415, 514438, 514451, 514824, 514861, 514863, 514864, 514886, 514902, 514903, 546 21, 546336, 546337, 548112, 549 6, 549216, A61K 3116, A61K 3138, A61K 3140, A61K 3144
Patent
active
058309152
ABSTRACT:
The invention provides compounds which are useful as inhibitors of matrix metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I) ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are described in the claims, a stereoisomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable alkoxyamide, ester acyloxyamide, imide or derivative thereof.
Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by matrix metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
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De Biswanath
McDow-Dunham Kelly Lynn
Pikul Stanislaw
Taiwo Yetunde Olabisi
Hake Richard A.
McMahon Mary Pat
O'Sullivan Peter
Suter David L.
The Procter & Gamble & Company
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