Enteric coated diltiazem once-a-day formulation

Details Enteric coated diltiazem once-a-day formulation Enteric coated diltiazem once-a-day formulation

1996-06-21

1998-11-03

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424482, 424481, 424462, 424461, 424458, 424457, 424456, A61K 932, A61K 934, A61K 936, A61K 956

Patent

active

058305033

ABSTRACT:
A once-a-day diltiazem dosage form which comprises: (a) a core element which is a compressed tablet which contains a therapeutic dose of diltiazem and an amount of a solubility modulating substance that controls the release of said diltiazem in order to provide a therapeutic level over a period of about 24 hours; and (b) on the outer surface of the core element, a sufficient amount of an enteric coating that causes the diltiazem to release at a rate that permits the use of once-a-day dosing to maintain steady state therapeutic levels of diltiazem.

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