Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1998-06-18
1999-10-12
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
4353201, 435325, 4352523, 536 232, C12Q 168, C12N 1500, C12N 120, C07H 2104
Patent
active
059653698
ABSTRACT:
The invention provides human succinyl-CoA synthetase holoenzyme (SCSH) and polynucleotides which identify and encode SCSH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of SCSH.
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Bridger, W.A. et al., "The Subunits of Succinyl-coenzyme A Synthetase--function and assembly", Biochem.Soc.Symp. 54:103-111 (1987).
Um, H.D. and Klein, C., "Evidence for Allosteric Regulation of Succinyl-CoA Synthetase", Biochem.J. 295:821-826 (1993).
Collier, G.E. and Nishimura, J.S., "Affinity Labeling of Succinyl-CoA Synthetase from Porcine Heart and Escherichia coli with Oxidized Coenzyme A Disulfide", J.Biol.Chem. 253:4938-4943 (1978).
Gougoux, A. et al., "Effect of Acetazolamide on Renal Metabolism and Ammoniagenesis in the Dog", Kidney Int. 31:1279-1290 (1987).
Ryan, D.G. et al., (GI 2258465), GenBank Sequence Database (Accession AF008588), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Bridger, W.A., (GI 164668), GenBank Sequence Database (Accession L06944), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894.
Srere, P.A., "Citric Acid Cycle" Methods in Enzymology 13:3-11 (1969).
Bandman Olga
Corley Neil C.
Lal Preeti
Patterson Chandra
Incyte Pharmaceuticals Inc.
Monshipouri Maryam
Wax Robert A.
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