Cephalosporin derivatives and bactericides containing the same

Details Cephalosporin derivatives and bactericides containing the same Cephalosporin derivatives and bactericides containing the same

1986-06-09

1988-07-19

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540225, 540226, 540227, C07D50136, A61K 31545

Patent

active

047585579

ABSTRACT:
Cephalosporin compounds represented by the following formula (I) and pharmaceutically acceptable salts thereof have a broad bactericidal spectrum against various pathogenic bacteria including Psuedomonas aeruginosa and are useful as bactericidal remedies for pathogenic diseases of human and animals: ##STR1## wherein A represents an unsubstituted or substituted pyridylthio group of a formula (I-1); ##STR2## or an unsubstituted or substituted pyridiniumthio group of a formula (I-2): ##STR3## or an unsubstituted or substituted pyridinium group of a formula (I-3); ##STR4## or a 5- or 6-membered heterocyclicthio or bicycloheterocyclicthio group of a formula (I-4):

REFERENCES:
patent: 4265892 (1981-05-01), Kocsis et al.
patent: 4370327 (1983-01-01), Wetz et al.
patent: 4393058 (1983-07-01), Makabe et al.
patent: 4547494 (1985-10-01), Oine et al.
Ichimoto et al., Agr. Biol. Chem., vol. 31, No. 8, pp. 979-989 (1967).
Heterocyclic Compounds, Pyridine and Derivatives, vol. 14, Parts I thru IV, Published by Interscience Publishers, (1975).
Ochiai et al., Journ. of Antibiotics, pp. 1022-1030, (1980).
Earl et al., Journ. of Org. Chem., 4787-4799 (1984).

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