Method for producing naringenin derivatives from xanthohumol

Details Method for producing naringenin derivatives from xanthohumol Method for producing naringenin derivatives from xanthohumol

2006-02-07

2011-11-29

Kosar, Andrew D (Department: 1622)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

08067622

ABSTRACT:
The present invention relates to an efficient method for producing naringenin derivatives from xanthohumol or derivatives thereof. In particular, the method according to the present invention provides the production of isoxanthohumol, for example also in enantiomer-enriched form, from xanthohumol and subsequent demethylation of isoxanthohumol according to specific procedures obtaining corresponding naringenin derivatives, such as, in particular, 8-prenylnaringenin.

REFERENCES:
International Search Report and Written Opinion, Application No. PCT/EP2006/001061, dated Apr. 25, 2006.
Hansel et al.; Desmethylxanthohumol: Isolierung aus Hopfen and Cyclisierung zu Flavanonen; Arch. Pharm. (Weinhelm) 321. 37-40 (1988).
Wang et al.; “A Facile Synthetic Approach to Prenylated Flavanones: First Total Synthesis of (±) Bonannione A and (±)-Sopharaflavanone A”; J. Nat. Prod., 2001, 64, 196-199.

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