5-Quinolinylpyridinones, cardiotonic compositions and methods

Details 5-Quinolinylpyridinones, cardiotonic compositions and methods 5-Quinolinylpyridinones, cardiotonic compositions and methods

1991-01-03

1992-08-25

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

546167, A01N 5502, C07D40104

Patent

active

051419319

ABSTRACT:
6-Alkyl-5-(6, or 7-quinolinyl)-3-(substituted)-2(1H)-pyridinones useful as cardiotonics are synthesized by reaction of trialkylquinolinylstannanes with 6-alky-5-halo-3-(substituted)-2(1H)-pyridinones. Compositions containing these pyridinones and methods of using them to treat congestive heart failure are provided.

REFERENCES:
patent: 4313951 (1982-02-01), Lesher et al.
patent: 4517192 (1985-05-01), Lesher
patent: 4559352 (1985-12-01), Lesher et al.
patent: 4595762 (1986-06-01), Lesher et al.
patent: 4710507 (1987-12-01), Campbell
patent: 4785005 (1988-11-01), Campbell et al.
Chemical Abstracts, vol. 109 No. 11, #92799n, 1987, Gil et al., "Preparation of pyridinone derivatives as cordiotonic agents".
Echavarren and Stille, "Palladium-Catalyzed Coupling of Aryl Triflates with Organostannanes", J. Am. Chem. Soc. 109:5478-5486 (1987).

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