Amorphous substance of tricyclic triazolobenzazepine derivative

Details Amorphous substance of tricyclic triazolobenzazepine derivative Amorphous substance of tricyclic triazolobenzazepine derivative

2007-06-12

2007-06-12

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S521000

Reexamination Certificate

active

10500071

ABSTRACT:
Disclosed are 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H), 10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine, which has been rendered amorphous and possesses improved absorption and dissoluvability, and a pharmaceutical composition comprising the same. Also disclosed are processes for producing 2-(1-isopropoxycarbonyloxy-2-methylpropyl)-7,8-dimethoxy-4(5H), 10-dioxo-2H-1,2,3-triazolo[4,5-c][1]benzazepine, which has been rendered amorphous, and a pharmaceutical composition comprising the same.

REFERENCES:
patent: 6372735 (2002-04-01), Ohtsuka et al.
patent: 99/16770 (1999-04-01), None
Hancock et al. (Pharmaceutical Research, vol. 17, No. 4, 2000).

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