Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-07-18
2006-07-18
Goldberg, Jeanine A. (Department: 1634)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C435S006120, C435S320100, C435S325000
Reexamination Certificate
active
07078513
ABSTRACT:
The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
REFERENCES:
patent: 4399216 (1983-08-01), Axel et al.
patent: 4434156 (1984-02-01), Trowbridge
patent: 4511503 (1985-04-01), Olson et al.
patent: 4666927 (1987-05-01), Hider et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4711845 (1987-12-01), Gelfand et al.
patent: 4912118 (1990-03-01), Hider et al.
patent: 5075469 (1991-12-01), Chevion
patent: 5104865 (1992-04-01), Hider et al.
patent: 5116964 (1992-05-01), Capon
patent: 5185368 (1993-02-01), Peter et al.
patent: 5256676 (1993-10-01), Hider et al.
patent: 5328992 (1994-07-01), Peter et al.
patent: 5385918 (1995-01-01), Connell et al.
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5420008 (1995-05-01), Nishida et al.
patent: 5424057 (1995-06-01), Peter et al.
patent: 5582979 (1996-12-01), Weber
patent: 5719125 (1998-02-01), Suzuki et al.
patent: 5872237 (1999-02-01), Feder
patent: 6025130 (2000-02-01), Thomas et al.
patent: 2115221 (1994-08-01), None
patent: 2115222 (1994-08-01), None
patent: 2115224 (1994-08-01), None
patent: 208 609 (1984-04-01), None
patent: 4 327 226 (1995-02-01), None
patent: 0 315 434 (1989-05-01), None
patent: 0 346 281 (1989-12-01), None
patent: 2 293 269 (1996-03-01), None
patent: WO 94/01463 (1994-01-01), None
patent: WO 94/04186 (1994-03-01), None
patent: WO 94/11367 (1994-05-01), None
patent: WO 94/21243 (1994-09-01), None
patent: WO 95/16663 (1995-06-01), None
patent: WO 96/06583 (1996-03-01), None
patent: WO 96/17870 (1996-06-01), None
patent: WO 96/35802 (1996-11-01), None
Camaschella, C. and Piperno, A., Hereditary hemochromatosis: recent advances in molecular genetics and clinical mangement. Haematologica. 82:77-84, 1997.
Hashimoto, K, et al. Identification of a mouse homolog for the human haemochromatosis candidate gene. Biochem. Biophys. Res. Comm. 230:35-39, 1997.
Luo, Dan. “A new solution for improving gene delivery.” TRENDS in Biotec. vol. 22, No. 3, Mar. 2004.
Hillier et al. (Genbank Accession No. R47761, May 18, 1995).
Hillier-2 et al. (Genbank Accession No. R07696, Apr. 1995).
Hillier et al. “Soares fetal liver spleen 1NFLSHomo sapienscDNA clone, mRNA sequences.” Genbank Accession No. R12707, Apr. 1995.
Vogel, F. et al., “Human Chromosomes,” Springer-Verlag (1992) pp. 18-81 (ISBN 3-540-09459-8).
Abravaya, K., et al., “Detection of Point Mutations With a Modified Ligase Chain Reaction(Gap-LCR),” Nucl. Acids Res. (1995) 23(4):675-682 (Abbott Laboratories).
Bacon, B.R., “Causes of Iron Overload,” N. Engl. J. Med. (1992) 326(2):126-127 (St. Louis Univ. School of Medicine).
Barany, F., “Genetic Disease Detection and DNA Amplification Using Cloned Thermostable Ligase,” Proc. Natl. Acad. Sci. USA (1991) 88:189-193 (National Institutes of Health).
Barton, J.C., et al., “Blood Lead Concentrations in Hereditary Hemochromatosis,” J. Lab. Clin. Med. (1994) 124(2):193-198 (0022-2143/94).
Barton, J.C., et al., “Hemochromatosis: The Genetic Disorder of the Twenty-First Century,” Nature Medicine (1996) 2(4):394-395 (Brookwood Medical Center).
Beutler, E., et al., “A Strategy for Cloning the Hereditary Hemochromatosis Gene,” Blood Cells, Molecules, and Diseases (1995) 21(21):207-216 (1079-9796/95).
Bjorkman, P.J., et al., “Structure, Function, and Diversity of Class l Major Histocompatibility Complex Molecules,” Annu. Rev. Biochem. (1990) 59:253-288 (0066-4154/90).
Calandro, L.M., et al., “Characterization of a Recombinant That Locates the Hereditary Hemochromatosis Gene Telomeric to HLA-F,” Hum. Genet. (1995) 96:339-342 (Kaiser Foundation Research Institute).
Camaschella, C., et al., “Hereditary Hemochromatosis: Recent Advances in Molecular Genetics and Clinical Management,” Haematologica (1997) 82:77-84 (BioMed).
Capecchi, M.R., “Altering the Genome by Homologous Recombination,” Science (1989) 244:1288-1292 (Univ. of Utah Medical Center).
Cartwright, G.E., et al., “Inheritance of Hemochromatosis: Linkage to HLA,” Trans. Assoc. Am. Phys. (1978) 91:273-281 (National Institutes of Health).
Chen, X., et al., “Template-Directed Dye-Terminator Incorporation(TDI)Assay: A Homogeneous DNA Diagnostic Method Based on Fluorescence Resonance Energy Transfer,” Nucl. Acids Res. (1997) 25(2):347-353 (U.S. Dept. of Energy).
Cotton, R.G.H., et al., “Reactivity of Cytosine and Thymine in Single-Base-Pair Mismatches With Hydroxylamine and Osmium Tetroxide and its Application to the Study of Mutations,” Proc. Natl. Acad. Sci. USA (1988) 85:4397-4401 (Nuffield Foundation).
Crawford, D.H.G., et al., “Evidence That the Ancestral Haplotype in Australian Hemochromatosis Patients May be Associated With a Common Mutation in the Gene,” Am. J. Hum. Genet. (1995) 57:362-367 (0002-9297/95).
Crystal, R.G., “Gene Therapy Strategies for Pulmonary Disease,” Am. J. Med. (1992) 92(6A):6A-44S-6A-52S (National Institutes of Health).
Darnell, J., “Tools of Molecular Cell Biology: Molecular Technology,” Scientific American Books (1986) pp. 227-229 (Rockefeller Univ.).
Dugast, I.J., et al. “Identification of Two Human Ferritin H Genes on the Short Arm of Chromosome 6,” Genomics (1990) 6:204-211 (0888-7543/90).
Edwards, C.Q., et al., “The Locus for Hereditary Hemochromatosis Maps Between HLA-A and HLA-B,” Cytogenet. Cell Genet. (1985) 40:620 (Univ. of Utah Medical Center).
Edwards, C.Q., et al., “Screening for Hemochromatosis,” New Engl. J. Med. (1993) 328(22):1616-1619 (Univ. of Utah College of Medicine).
El Kahloun, A., et al., “Localization of Seven New Genes Around the HLA-A Locus,” Hum. Molec. Genet. (1992) 2(1):55-60 (Institut National de la Sante et de la Recherche Medicale).
Fahy, E., et al., “Self-Sustained Sequence Replication(3SR): An Isothermal Transcription-Based Amplification System Alternative to PCR,” PCR Methods and Applications (1991) 1:25-33 (1054-9803/91).
Feder, J.N., et al., “A Novel MHC Class-I-Like Gene is Mutated in Patients With Hereditary Haemochromatosis,” Nature Genet. (1996) 13:399-408 (Mercator Genetics).
Finch, C.A., “Hemochromatosis—Treatment is Easy, Diagnosis Hard,” Western J. Med. (1990) 153(3):323-325 (Univ. of Washington School of Medicine).
Fischer, S.G., et al., “DNA Fragments Differing by Single Base-Pair Substitutions are Separated in Denaturing Gradient Gels: Correspondence With Melting Theory,” Proc. Natl. Acad. Sci. USA (1983) 80:1579-1583 (National Institutes of Health).
Friedmann, T., “Progress Toward Human Gene Therapy,” Science (1989) 244:1275-1281 (San Diego Univ. of Calif.).
Fullan, A., et al., “A Polymorphic Dinucleotide Repeat at the Human HLA-F Locus,” Hum. Mol. Genet. (1994) 3(12):2266 (Mercator Genetics).
Gasparini, P., et al., “Linkage Analysis of 6p21 Polymorphic Markers and the Hereditary Hemochromatosis: Localization of the Gene Centromeric to HLA-F,” Hum. Molec. Genet. (1993) 2(5):571-576 (National Research Council).
Gnirke, A., et al., “Physical Calibration of Yeast Artificial Chromosome Contig Maps by RecA-Assisted Restriction Endonuclease(RARE)Cleavage,” Genomics (1994) 24:199-210 (0888-7543/94).
Goei, V.L., et al., “Isolation of Novel Non-HLA Gene Fragments From the Hemochromatosis Regio
Drayna Dennis T.
Feder John N.
Gnirke Andreas
Ruddy David
Thomas Winston J.
Bio-Rad Laboratories, Inc.
Goldberg Jeanine A.
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