Neurogenic compositions and methods

Details Neurogenic compositions and methods Neurogenic compositions and methods

2005-06-07

2005-06-07

Eyler, Yvonne (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C424S198100, C514S002600, C435S069100

Reexamination Certificate

active

06903188

ABSTRACT:
The present invention has found that the Mts1 protein is expressed in white matter astrocytes in the spinal cord. Such expression is significantly increased following sciatic nerve injury or dorsal root injury, particularly in astrocytes surrounding dorsal funiculus containing the central processes of the injured primary sensory neurons. The present invention has further demonstrated that Mts1 proteins administered extracellularly promote neurite outgrowth from neuronal cells. Based on these surprising findings, the present invention provides compositions and methods that are useful for the treatment of various neurological conditions characterized by death, degeneration or injury of neuronal cells.

REFERENCES:
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patent: 5801142 (1998-09-01), Zain et al.
patent: WO 92/10200 (1992-06-01), None
patent: WO 95/20656 (1995-08-01), None
Ebralidze, A., et al. (1989) “Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+ −binding protein family”, Genes and Development, US, Cold Spring Harbor, NY, vol. 3, 1994, pp. 1086-1093.
Klingman, D., et al. “The S100 Protein Family”, Trends in Biochemical Sciences, vol. 13, No. 11, 1988, pp. 437-443.
Winningham-Major, F., et al. (1989) “Neurite Extension and Neuronal Survival Activities of Recombinant S100B Proteins That Differ in The Content and Position of Cysteine Residues”, The Journal of Cell Biology, vol 109, pp. 3063-3071.
Azmitia, E.C., et al. (1990) “S-100B but not NGF, EGF, insulin or calmodulin is a CNS serotonergic growth factor”, Elsevier Science Publishers B.V. (Biomedical Division).
Ebralidze, A., et al. (1989) “Isolation and characterization of a gene specifically expressed in different metastatic cells and whose deduced gene product has a high degree of homology to a Ca2+-binding protein family”,Genes&Development 3: 1086-1093.
Kozlova, E. N., et al. (1999) “Metastasis-Associated Mts1 (S100A4) Protein Is Selectively Expressed in White Matter Astrocytes and Is Up-Regulated After Peripheral Nerve or Dorsal Root Injury”,GLIA 27:249-258.

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