Process for producing optically active ethyl (3R, 5S,...

Details Process for producing optically active ethyl (3R, 5S,... Process for producing optically active ethyl (3R, 5S,...

2005-09-20

2005-09-20

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S174000

Reexamination Certificate

active

06946557

ABSTRACT:
The objective of this invention is to provide a process for producing an optically active isomer of ethyl 7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate by optically resolving an optical isomer mixture of the compound at a high productivity. The process is characterized by employing a filler comprising a carrier and a specific amount of cellulose tris (4-chlorophenyl carbamate) supported the carrier and carrying out chromatographic separation under the condition that the capacity factors have specific values.

REFERENCES:
patent: 5939552 (1999-08-01), Ikeda et al.
patent: 747341 (1996-12-01), None
Nagamatsu, J of Chromatography A, 832, pp55-65, 1999.
Kojima, CA 130:332232, abstract of Biological & Pharmaceutical Bulletin, 22(2), pp 142-150, 1999.
Nagamatsu et al., Chiral Separation of a Pharmaceutical Intermediate by a Simulted Moving Bed Process, J. Chromatogr., A, (1999), vol. 832, pp. 55-65.
Chiral separation of a pharmaceutical intermediate by a simulated moving bed process, Journal of Chromatography A, 832 (1999) 55-65.

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