Ultrasound apparatus and method for augmented clot lysis

Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation

Reexamination Certificate

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Reexamination Certificate

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06945937

ABSTRACT:
An apparatus and method for using ultrasound augmented with microbubbles, thrombolytic drugs or other agents for clot lysis wherein at least one ultrasound transducer generates a plurality of acoustic signals and time, amplitude, phase and frequency modulation of the signals provide more uniform power delivery with fewer gaps in the ultrasound field. Interference patterns from one or multiple transducers are constantly shifted in position. A phased array of transducers may generate a beam that is swept over the area to be treated. In another embodiment, an array of transducers may generate ultrasound at a number of slightly varying frequencies to produce an interference pattern that sweeps in and out through the targeted tissue. A single array may be used to produce both effects simultaneously or separately.

REFERENCES:
patent: 5524620 (1996-06-01), Rosenschein
patent: 5582176 (1996-12-01), Swerling et al.
patent: 5648098 (1997-07-01), Porter
patent: 5695460 (1997-12-01), Siegel et al.
patent: 5980950 (1999-11-01), Porter
patent: 6113570 (2000-09-01), Siegel et al.
patent: 6126619 (2000-10-01), Peterson et al.
patent: 6139819 (2000-10-01), Unger et al.
patent: 6197345 (2001-03-01), Porter
patent: 6416740 (2002-07-01), Unger
patent: 6514220 (2003-02-01), Melton, Jr. et al.
patent: 6548047 (2003-04-01), Unger
patent: 6575922 (2003-06-01), Fearnside et al.
patent: 6716412 (2004-04-01), Unger
patent: 2001/0008880 (2001-07-01), Porter
patent: 2001/0031243 (2001-10-01), Unger
patent: 2002/0082529 (2002-06-01), Suorsa et al.
patent: 2002/0095087 (2002-07-01), Mourad et al.
patent: 2002/0107473 (2002-08-01), Bond et al.
patent: 2002/0193708 (2002-12-01), Thompson et al.
patent: 2004/0059220 (2004-03-01), Mourad et al.
patent: 2005/0015009 (2005-01-01), Mourad et al.
Bravata, D., et al., Thrombolysis for Acute Stroke in Routine Clinical Practice, Arch Intern Med, vol. 162, pp. 1994-2001, Sep. 23, 2002.
Nishioka, T., et al., Dissolution of Thrombotic Arterial Occlusion by High Intensity, Low Frequency Untrasound and Dodecafluoropentane Emulsion: An In Vitro and In Vivo Study, Journal of the American College of Cardiology, vol. 30, No. 2, pp. 561-568, Aug. 1997.
Tachibana, K., et al., Albumin Microbubble Echo-Contrast Material as an Enhancer for Ultrasound Accelerated Thrombolysis, Circulation, vol. 92, No. 5, pp. 1148-1150, Sep. 1, 1995.
Alexandrov, A., et al., High Rate of Complete Recanalization and Dramatic Clinical Recovery During tPA Infusion When Continuously Monitored with 2-MHz Transcranial Doppler Monitoring, Stroke, vol. 31, pp. 610-614, Mar. 2000.
Schmulling, S., et al., One-Year Follow-Up in Acute Stroke Patients Treated with rtPA in Clinical Routine, Stroke, vol. 31, pp. 1552-1554, Jul. 2000.
Daffertshofer, M., et al., Therapeutic Ultrasound in Ischemic Stroke Treatment: Experimental Evidence, European Journal of Ultrasound, vol. 16, pp. 121-130, Nov. 2002.
Culp, W., et al., Microbubble-augmented Ultrasound Declotting of Thrombosed Arteriovenous Dialysis Grafts in Dogs, J Vasc Interv Radiol, vol. 14, No. 3, pp. 343-347, Mar. 2003.
Culp, W., et al., Microbubble Potentiated Ultrasound as a Method of Declotting Thrombosed Dialysis Grafts: Experimental Study in Dogs, Cardiovascular and Interventional Radiology, vol. 24, pp. 407-412, published online Nov. 8, 2001.

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