Heteroaryl-substituted deoxy glycero-phosphoethanolamines

Details Heteroaryl-substituted deoxy glycero-phosphoethanolamines Heteroaryl-substituted deoxy glycero-phosphoethanolamines

1995-06-07

1998-01-13

McKane, Joseph K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 80, 514 91, 514 92, 514 94, 424400, 424450, 548112, 548113, 548413, 548414, C07D23358, C07D24908, A61K 3141, A61K 31415

Patent

active

057079781

ABSTRACT:
Therapeutically active, heteroaryl-substituted deoxy glycero-phosphoethanolamines are disclosed having the general Formula I: ##STR1## wherein one of X, Y or Z is a fatty ether substituent, one is a heteroaryl ring substituent with 1-4 nitrogens as the only heteroatoms, one of which is bonded to a carbon of the glyceryl backbone, and one is a phosphoethanolamine substituent substituted at the nitrogen, provided that each of X, Y and Z is a different substituent, and the pharmaceutical compositions comprising the therapeutically active compounds and methods of using the therapetically active compounds to treat cancerous tumors, psoriasis and inflammation are also disclosed.

REFERENCES:
patent: 4372949 (1983-02-01), Kodama et al.
patent: 4650791 (1987-03-01), Nomura et al.
patent: 5116992 (1992-05-01), Braquet et al.

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