Esters of normal butyric acid and their use as pharmaceuticals

Details Esters of normal butyric acid and their use as pharmaceuticals Esters of normal butyric acid and their use as pharmaceuticals

1990-03-29

1993-02-09

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536115, 536119, 536120, 514 25, C07H 1302, C07H 1504, A61K 3170

Patent

active

051854368

ABSTRACT:
Compounds which are hydrolyzed in vivo to n-butyric acid are esters of butyric acid in which the alcohol group is selected from the group consisting of polyhydric alcohols, cyclic and acyclic aldose or ketose monosaccharides and their acetonides. Of particular interest are O-butanoyl-6-O-ispropylidene-1,2,.alpha. O-glucofuranose, tri-O-butanoyl 3, 5, 6,- isopropylidene-1,2 .alpha.-D-glucofuranose, O-butanoyl-6-di-O-isopropylidene-1,2 : 3,4 .alpha.-D-galactopyranose, and penta-O-butanoyl-1,2,3,4,6 D-galactopyranose and penta-O-butanoyl-1,2,3,4,6.alpha. D-galactopyranose, )-n-butanoyl-1-isopropylidene-2,3 glyceryl, O-butanoyl-3-di-o-palmitoyl-1,2 glyceryl, and di-O-n butanoyl-2,3 O-palmitoyl-1 glyceryl.

REFERENCES:
patent: 4497649 (1985-02-01), Loh
J. Chem. Soc (C), issued 1966, Jill Gigg & Roy Gigg, "The Allyl Ethers as a Protecting Group in Carbohydrate Chemistry", see p. 82.

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