Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2011-06-28
2011-06-28
Chernyshev, Olga N (Department: 1649)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S017700, C514S018200, C514S018400
Reexamination Certificate
active
07968517
ABSTRACT:
The present invention provides a method for preventing or treating opiate tolerance and dependence by administering to an individual in need of such treatment with a pharmaceutically effective amount of a blocking reagent for ephrinB-EphB signaling. The opiate tolerance and dependence can be caused by chronic morphine treatment and withdrawal. The blocking reagent can be an EphB receptor blocker such as EphB1-Fc and EphB2-Fc.
REFERENCES:
patent: WO 2004/005345 (2004-01-01), None
Liu, et al., “EphB receptor signaling in mouse spinal cord contributes to physical dependence on morphine,”The FASEB Journal, 23:1-10 (2009).
Han et al., “Targeted mutation of EphB1 receptor prevents development of neuropathic hyperalgesia and physical dependence on morph ne in mice,”Molecular Pain, 4(60):1-12 (2008).
Liu et al., “EphB receptor signaling in mouse spinal cord contributes to physical dependence on morphine,”Society for Neuroscience Annual Conference, Presentation Abstract (Nov. 2008).
Liu et al., “Activation of ephrinB-EphB receptor signaling modulates behavioral signs of opioid withdrawal,”Society for Neuroscience Annual Conference, Presentation Abstract (Nov. 2007).
Liu et al., “Spinal matrix metalloproteinase-9 contributes to physical dependence on morphine in mice,”J. of Neuroscience, 30(22):7613-7623, 2010.
Chernyshev Olga N
Parker College of Chiropractic
SNR Denton US LLP
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