Aspartyl protease inhibitors

Details Aspartyl protease inhibitors Aspartyl protease inhibitors

1996-09-30

1999-08-31

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514252, 5142358, 514307, 514341, 514362, 514369, 514397, 514398, 514400, 514409, 514418, 544 6, 544133, 544165, 544357, 544360, 544363, 544370, 546210, 5462784, 548134, 548214, 5483154, 5483235, 54832401, 5483405, 548550, 548517, A61K 41315, A61K 3143, A61K 3147, A61K 3144, A61K 3141, A61K 31425, A61K 31415, A61K 3140

Patent

active

059454130

ABSTRACT:
This invention relates to a novel class of compounds that are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting aspartyl protease activity and methods for treating viral infections using the compounds and compositions of this invention.

REFERENCES:
patent: 3882120 (1975-05-01), Piesch et al.
patent: 4413130 (1983-11-01), White
patent: 5288873 (1994-02-01), Su et al.
patent: 5436351 (1995-07-01), Coffey et al.
Marquez et al, J. Org. Chem., vol. 37, No. 16, pp 2558 to 2561 (1972).

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