Methods and compositions for preventing and treating bone loss

Details Methods and compositions for preventing and treating bone loss Methods and compositions for preventing and treating bone loss

1997-12-03

1999-08-31

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514171, 514284, A61K 3158, A61K 3156, A61K 3144

Patent

active

059454121

ABSTRACT:
The present invention provides for a method of inhibiting bone loss in a subject in need of such treatment comprising administration to the subject of a therapeutically effective amount of a compound of structural formula I: ##STR1## The present invention further provides for a method for treating and preventing osteoporosis and osteopenia and other diseases where inhibiting bone loss may be beneficial, including: Paget's disease, malignant hypercalcemia, periodontal disease, joint loosening and metastatic bone disease, comprising administration of therapeutically effective amount of a compound of structural formula I to the subject.
Further, the present invention provides for compositions useful in the methods of the present invention, as well as a method of manufacture of a medicament useful for inhibiting bone loss and treating or preventing osteoporosis and osteopenia.

REFERENCES:
patent: 5512555 (1996-04-01), Waldstreicher
patent: 5543417 (1996-08-01), Waldstreicher
patent: 5550134 (1996-08-01), Audia et al.
patent: 5670514 (1997-09-01), Audia et al.
Durette et al., Database Caplus on STN, 1995.
Durette et al., Database Caplus on STN, 1993.
Rosen et al., Endocrinology 136 (1995), pp. 1381-1387, "Bone density is normal in male rats treated with finasteride."
Tollin et al., J. Clin. Endoc. Metab. 81 (1996), pp. 1031-1034, "Finasteride therapy does not alter bone turnover in men with benign prostatic hyperplasia. . . ".
Matzkin et al., Clin. Endocrinol. 37 (1992), pp. 432-436, "Prolonged treatment with finasteride (a 5alpha-reductase inhibitor) does not affect bone density and metabolism."

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