Food or edible material: processes – compositions – and products – Products per se – or processes of preparing or treating... – Protein – amino acid – or yeast containing
Patent
1997-11-19
1999-12-28
McKane, Joseph K.
Food or edible material: processes, compositions, and products
Products per se, or processes of preparing or treating...
Protein, amino acid, or yeast containing
514365, 514367, 514398, 514399, 514400, 514561, 514562, 548152, 548161, 548164, 548179, 548180, 548190, 548193, 548194, 548202, 548203, 548204, 548205, 5483265, 5483311, 5483315, 562555, 562557, A61K 3138, C07D27724
Patent
active
060078650
ABSTRACT:
The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.
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Cerami Anthony
Egan John J.
Hwang San-Bao
Ulrich Peter C.
Vasan Sara
Alteon Inc.
McKane Joseph K.
The Picower Institute for Medical Research
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