Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1993-05-07
1998-03-24
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
558 45, 514 80, 514 81, 514 86, 514 89, 514 92, 514 94, 514114, 514127, 544232, 544243, 544244, 540471, 540450, 540474, 540542, 546 22, 546 23, 548112, 548113, 562 11, 562 17, 562 23, 562 24, C07F 1300, C07F 1502, C07F 938, C07F 940, C07F 958, C07D21369, C07C14368, A61K 4900
Patent
active
057312990
ABSTRACT:
The present invention relates to phosphonsulfonates and the pharmaceutically-acceptable salts and esters thereof, having the following structure according to formula (I): ##STR1## The present invention further relates to pharmaceutical compositions containing a safe and effective amount of a compound of the present invention, and pharmaceutically-acceptable excipients. Finally, the present invention relates to methods for treating or preventing pathological conditions characterized by abnormal calcium and phosphate metabolism in humans or other mammals, including treating or preventing osteoporosis and arthritis, especially rheumatoid arthritis and osteoarthritis. This method comprises administering to a human or other mammal in need of such treatment of a safe and effective amount of a compound or composition of the present invention.
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Bayless Allan Vincent
Dansereau Susan Mary
Ebetino Frank Hallock
Hake Richard A.
Higel Floyd D.
Roof Carl J.
Suter David L.
The Procter & Gamble & Company
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