Trans-hexahydro-pyrido-indoles

Details Trans-hexahydro-pyrido-indoles Trans-hexahydro-pyrido-indoles

1978-05-22

1979-11-13

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 86, C07D47104

Patent

active

041744535

ABSTRACT:
Certain trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido-[4,3-b]indoles are useful as analgesics and sedatives. Some are also useful as major (antipsychotics) and/or minor (anxiolytics) tranquilizers, muscle relaxants, or hypotensives. The compounds of this invention are made by (1) reaction of .DELTA..sup.4a,9b -tetrahydro precursors with borane/THF and (2) acidifying the reaction product by which it is reduced and hydrolyzed to form the corresponding trans-hexahydro compound.

REFERENCES:
Berger, J., et al., Tett. Lett., 1807-1810 (1975).
Littell, R., et al., J. Org. Chem., 38, 1504-1510 (1973).
Gurney, J., et al., J. Chem. Soc., 2676 (1927).

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