Detection of Neisseria bacteria by immunoassay

Details Detection of Neisseria bacteria by immunoassay Detection of Neisseria bacteria by immunoassay

1977-09-28

1981-01-13

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

424 12, 23230B, C12Q 166

Patent

active

042450381

ABSTRACT:
This invention is concerned with means for determining the presence of Neisseria bacteria in a fluid sample, the method contemplating the release of an enzyme from the bacteria upon lysis which can be detected via the use of antibodies specific to the enzyme. Thus, inhibition of enzyme activity resulting from the presence of antibodies specific to the enzyme can be readily monitored. The enzyme released from the bacteria upon lysis is capable of oxidizing 1,2-propanediol and reducing nicotinamide-adenine-dinucleotide (NAD). The full structure of the enzyme is not understood but, because of those two substantive characteristics, the enzyme has been denominated 1,2-propanediol dehydrogenase. In sum, the instant invention combines the sensitivity of an enzymatic reaction with the specificity of an immunoassay.

REFERENCES:
patent: 3875011 (1975-04-01), Rubenstein et al.
patent: 3974269 (1976-08-01), Maley
patent: 4029756 (1977-06-01), Gaafar
patent: 4066744 (1978-01-01), Price et al.

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