Methods of inhibiting syp binding to a CTLA-4 receptor

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 721, 435 724, 530351, 530350, 530300, G01N 3353, G01N 33566

Patent

active

057861528

ABSTRACT:
Disclosed are methods for identifying a molecule that inhibits SYP activity in a T-cell.

REFERENCES:
patent: 5434131 (1995-07-01), Linsley et al.
patent: 5580979 (1996-12-01), Bachovchin
patent: 5607974 (1997-03-01), Droge et al.
Mahalingam et al., T cell activation and disease severity in HIV infection, Clin. Exp. Immunol., 93: 337-343, Sep. 1993.
Brunet et al., A new member of the immunoglobulin superfamily--CTLA-4, Nature 328: 267-270 (16 Jul. 1987).
Green et al., Absence of B7-Dependent Responses in CD28-Deficient Mice, Immunity, 1:501-508 (Sep. 1994).
Gribben et al., CTLA4 mediates antigen-specific apoptosis of human T cells, Proc. Natl. Acad. Sci. USA, 92: 811-815 (Jan. 1995).
Harper et al., The Journal of Immunology, 147: 1037-1044, No. 3, (Aug. 1, 1991).
Howard et al., Immunogenetics 33: 74-76 (1991).
Krummel et al., J. Exp. Med. 182: 459-465 (Aug. 1995).
Lane et al., J. Exp. Med. 179: 819-830 (Mar. 1994).
Linsley et al., Immunity 1: 793-801 (Dec. 1994).
Linsley et al., J. Exp. Med. 173: 721-730 (Mar. 1991).
Marengere et al., Science 272: 1170-1173 (24 May 1996).
Ronchese et al., J. Exp. Med. 179: 809-817 (Mar. 1994).
Tivol et al., Immunity 3: 541-547 (Nov. 1995).
Walunas et al., Immunity 1: 405-413 (Aug. 1994).
Waterhouse et al., Science 270: 985-988 (10 Nov. 1995).
Case et al., The Journal of Biological Chemistry 269, No. 14: 10467-10474, (Issue of Apr. 8, 1994).
Feng et al., Science 259: 1607-1611 (12 Mar. 1993).
Klinghoffer et al., The Journal of Biological Chemistry 270, No. 38: 22208-22217 (Issue of Sep. 22, 1995).
Pelicci et al., Cell 70:93-104 (10 Jul. 1992).
Seely et al., The Journal of Biological Chemistry 270, No. 32: 19151-19157 (Issue of Aug. 11, 1995).
Tauchi et al., The Journal of Biological Chemistry 270, No. 10: 5631-5635 (Issue of Mar.10, 1995).
Tauchi et al., The Journal of Biological Chemistry 269, No. 40: 25206-25211 (Issue of Oct. 7, 1994).
Tomic et al., The Journal of Biological Chemistry 270, No. 36: 21277-21284 (Issue of Sep. 8, 1995).
Yamauchi et al., The Journal of Biological Chemistry 270, No. 25: 14871-14874 (Issue of Jun. 23, 1995).
Doody et al., Science 269: 242-244 (14 Jul. 1995).
Law et al., J. Exp. Med. 183: 547-560 (Feb. 1996).
Pleiman et al., Immunology Today 15, No. 9: 393-399 (1994).
Freeman et al., Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation, Science, 626: 909-911, Nov. 1993.
Lindsten et al., Characterization of CTLA-4 structure and expression on human T cells, J. Immunol., 151(7): 3489-3499, Oct. 1993.
Linsley et al., The role of the CD28 receptor during T cell responses to antigen, Annu. Rev. Immunol., 11:191-212, 1993.
Linsley et al., Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation?, J. Exp. Med., 182: 289-292, Aug. 1995.
Linsley et al., Lymphocyte activation: T-cell regulation by CTLA-4, Curr. Biol., 6(4): 398-400, 1996.
Schneider et al., CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells, J. Exp. Med., 181: 351-355, Jan. 1995.
Sugimoto et al., Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2, J. Biol. Chem., 268 (30): 22771-22776, Oct. 1993.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods of inhibiting syp binding to a CTLA-4 receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of inhibiting syp binding to a CTLA-4 receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of inhibiting syp binding to a CTLA-4 receptor will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-22134

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.