Substituted cyclodextrin sulfates and their uses as growth modul

Details Substituted cyclodextrin sulfates and their uses as growth modul Substituted cyclodextrin sulfates and their uses as growth modul

1992-09-18

1995-08-15

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514908, 536103, A61K 3170, C08B 3702, C08B 3716

Patent

active

054419441

ABSTRACT:
The invention relates to highly water soluble substituted .alpha.-, .beta.- or .gamma.-cyclodextrin sulfates associated with a physiologically acceptable cation. Pathological or otherwise undesirable cell or tissue growth in mammals, including humans, is inhibited by administering thereto (1) a water-soluble substituted cyclodextrin sulfate salt, together with (2) a growth-inhibiting organic compound. The growth-inhibiting compound (2) may be asteroid having no inhibiting effect in the absence of (1), or an organic compound which may be an active growth inhibitor, the action of which is potentiated by (1). The invention provides a method for inhibiting angiogenesis and controlling the growth of tumors as well as treating other diseases and pathological conditions associated with undesired cell or tissue growth, including angiogenesis.

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