Method of inhibiting binding of PDGF to a PDGF receptor by biosy

Details Method of inhibiting binding of PDGF to a PDGF receptor by biosy Method of inhibiting binding of PDGF to a PDGF receptor by biosy

1993-07-21

1995-05-23

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 72, 435 72W, 435 732, 4352402, 4241431, 530324, 530350, 530399, C12Q 100, G01N 3353, A61K 3702, C07K 500

Patent

active

054181356

ABSTRACT:
Disclosed are polypeptides which antagonize the activity of platelet-derived growth factor (PDGF). These polypeptides include an amino acid sequence sufficiently duplicative of at least a portion of the amino acid sequence of an A chain of PDGF such that the polypeptides bind a cell membrane-bound receptor for native PDGF on a cell that responds biologically to the binding of PDGF. The binding of the antagonist to the receptor is effective to inhibit PDGF binding and activity. Also disclosed are methods of preparing and using these antagonists.

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