Preparation and use of viral vectors for mixed envelope protein

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

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4241601, 4241991, 4353201, 514 44, 536 232, A61K 4500, A61K 3942, A61K 3800, C12N 1500

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057414920

ABSTRACT:
Polyenv vaccines are provided that comprise mixtures of at least 4-40 to about 10,000 different recombinant vaccinia viruses that each express a different HIV env variant or a portion thereof containing both constant and variable regions, as well as methods of making and using such polyenv vaccines and vaccinia viruses, including the use of the polyenv vaccine, in live, attenuated or inactivated form, for prophylaxis or treatment of HIV infection.

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