System and method for regulation of gene expression

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4353201, 435325, 435375, 435410, 536 231, 536 232, C12P 2102, C12N 510, C12N 1510, C12N 1511

Patent

active

059687738

ABSTRACT:
The present invention provides a polynucleotide molecule coding for a protein operably linked to a tet operator sequence and at least two promoters. Preferably, the polynucleotide molecule is operably linked to a transrepressor fusion protein comprising a tet repressor and a transcription silencer protein domain.

REFERENCES:
patent: 5347075 (1994-09-01), Sorge
patent: 5464758 (1995-11-01), Gossen et al.
patent: 5510099 (1996-04-01), Short et al.
patent: 5589392 (1996-12-01), Short
Swiger, Roy R. et al. "A beta galactosidase reporter vector for mammalian cell lines," Environmental and Molecular Mutagenesis (1998) Vol. 31 No. Suppl 29 p. 28.
Baron V., et al. "Co-regulation of Two Gene Activities by Tetracycline via a Bidirectional Promoter," Nucleic Acids Research, vol. 23 No. 17, Sep. 11, 1995, page 3605/3606.
Deuschle V. et al. "Tetracycline-Reversible silencing of Eukaryotic Promoters", Molecular and Cellular Biology, vol. 15, No. Apr. 4, 1995 pp. 1907-1914.
Park, 1994 DNA and Cell Biology, vol. 13, No. 11; A .beta.-Galactosidase Expression Vector for Promoter Analysis.
Gossen et al. Oct. 1989 Proc. Natl. Acad. Sci. USA, vol. 86, pp. 7971-7975; Efficient rescue of integrated shuttle vectors from transgenic mice: A model for studying mutations in vivo.
Kolher, et al. Sep. 1991 Proc. Natl. Acad. Sci. USA, Vol. 88, pp. 7958-7962; Spectra of spontaneous and mutagen-induced mutations in the lacl gene in transgenic mice.
Gossen et al. Jun. 1992 Proc. Natl. Acad. Sci. USA, vol. 89, pp. 5547-5551; Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Furth, et al. Sep. 1994 Proc. Natl. Acad. Sci. USA, vol. 91, pp. 9302-9306; Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.
Deuschler, et al. Apr. 1995 Molecular and Cellular Biology, pp. 1907-1914; Tetracycline-Reversible Silencing of Eukaryotic Promoters.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

System and method for regulation of gene expression does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with System and method for regulation of gene expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and System and method for regulation of gene expression will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2054638

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.