Polycyclic dihydrothiazoles, their preparation, and use as pharm

Details Polycyclic dihydrothiazoles, their preparation, and use as pharm Polycyclic dihydrothiazoles, their preparation, and use as pharm

1999-09-29

2000-07-18

Stockton, Laura L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514338, 5462701, 548150, A61K 31428, C07D27760, C07D41706

Patent

active

060908335

ABSTRACT:
Polycyclic dihydrothiazoles, processes for their preparation, and their pharmaceutical uses are provided. Preferred compounds are represented by the formula I ##STR1## wherein the radicals may have various meanings. The compounds are particularly useful as anorectics.

REFERENCES:
patent: 2942003 (1960-06-01), Copeland
Hashem M.M. et al., "Novel pyrazolo, isoxazolo, and thiazolo steroidal systems and model analogs containing dimethoxylaryl (or dihydroxylaryl) groups and derivatives. Synthesis, spectral properties, and biological activity", J. of Med. Chem. vol. 19, No. 2, pp;229-239, (1976,)-XP000609112.
Perrone et al., "Conformationally restricted thiazole derivatives as novel class of 5-HT3, receptor ligands", IL Farmaco, 50, (2), pp. 77-82, (1995,)-XP000605205.
Yamane K., "Benzocycloheptathiazoles", Chemical Abstract, vol. 73, No. 9, (Aug. 31, 1970)-XP002018029.
Saida et al., "Preparation of thiazoles as tyrosinase inhibitors and skin-lightening preparations containing them", vol. 120, No. 2, (Jan. 10, 1994) -XP002123115.

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